![]() ![]() The skin of the average adult occupies a surface area of approximately 1.5–2.0 m 2 and constitutes one tenth of human body mass. Disorders or damage of such an extensive and multifunction organ as skin can be a serious threat to patient health or even life. Moreover, it is involved in perception and immunological response of the whole organism. The skin takes part in regulation of water and electrolyte homeostasis and plays a secretory role. The skin has many functions in humans, especially in the defense against physical, chemical or biological factors. This paper reviews the latest reports on the potential therapy of skin disorders through treatment with phenolic compounds, considering mostly a single specific compound or a combination of compounds in a plant extract. Polyphenols also act protectively and help prevent or attenuate the progression of certain skin disorders, both embarrassing minor problems (e.g., wrinkles, acne) or serious, potentially life-threatening diseases such as cancer. ![]() Due to their natural origin and low toxicity, phenolic compounds are a promising tool in eliminating the causes and effects of skin aging, skin diseases, and skin damage, including wounds and burns. Evidence suggests that people can benefit from plant phenolics obtained either by the diet or through skin application, because they can alleviate symptoms and inhibit the development of various skin disorders. Besides the beneficial effects on the plant host, phenolic metabolites (polyphenols) exhibit a series of biological properties that influence the human in a health-promoting manner. Phenolic compounds constitute a group of secondary metabolites which have important functions in plants. ![]()
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